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Using a nationally representative dataset from HINTS 2012, this study explores the interrelationships among absolute risk perceptions, comparative risk perceptions, negative affect, and cancer screening behaviors. In the first study, it was found that absolute risk (versus comparative risk) was a significant stronger predictor of some cancer screenings, including PSA test and Pap test on a 95% confidence interval, and mammography on a 90% confidence interval. The second study examined the mechanism that explains the association between risk perceptions and cervical cancer screening. It was demonstrated that cancer worry mediated the relationship between comparative risk perceptions and cervical cancer screening behavior. This provides empirical evidence that supports the more primacy role of affect (compared to risk perceptions) in the decision-making process of cervical cancer screening.