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Drawing from the optimal matching model (Cutrona & Russell, 1990), this study examined the relationships among strong-tie/weak-tie support network preference and health-related stigma for stress and depression among members of health-related computer-mediated support groups. The results indicated that health-related stigma was positively associated with preference for weak-tie support, and preference for weak-tie support was found to moderate the relationship between stigma and both stress and depression. The theoretical implications of these findings are discussed along with suggestions for how they can be integrated into future computer-mediated support interventions for people facing stigmatized health concerns.