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This study aims to investigate the impact of health communication messages on attitudes and behavioral intentions in the context of HPV vaccination. In particular, the current study examines how individual difference in Consideration of Future Consequences (CFC) and temporal message framing (i.e., present-oriented message and future-oriented message) interact to influence attitudinal and intentional outcomes. Results of a controlled experiment (N =416) showed a significant interaction effect of CFC and temporal framing on attitudes and intentions as a whole indicating high CFC individuals, compared to low CFC individuals, were more persuaded by present-oriented messages and less persuaded by future-oriented messages. These somewhat surprising findings are discussed in light of the unique characteristics of the HPV vaccine.