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This study examined the influence of endorser type (celebrity, regular people, product only), social identification, source credibility, self-brand connections, attention to social comparison, health consciousness, and social media use on brand outcomes in Instagram pages for an e-cigarette brand. Results of a between-subjects experiment revealed that endorser type significantly impacted brand attitude, brand trust, purchase intention, and perceived source credibility, with celebrity endorsers having the strongest effect. Social identification, self-brand connections, attention to social comparison, and health consciousness also moderated between endorser type and key dependent measures. Implications for future research and suggestions for regulation of e-cigarette advertising in social media are discussed.