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This study investigates discrete emotional reactions (fear, regret, anger, contentment, relief and optimism) and social cognitive perceptions resulting from health prevention messages. The messages vary in action-outcome frames (gain and loss) and experientiality (degree of personal insights into motivations and goals of preventive behavior) for two health prevention messages (n = 349). Results show appraisal-congruent patterns for effects of emotions on social cognitive perceptions and behavioural intentions.