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Public audience now can deliver and share their opinions of any given issue in society on social media. Through a content-analytic project, we investigated the public discussion about GM foods on a leading microblogging platform in China. Our research is a pioneering study exploring the presentations of risks, opportunities, and responsibilities associated with GM foods and their safety. We provided the most current and important evidence to document the societal resistance against GM foods and answered the question of who were held responsible to warrant the safety of GM foods.