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This paper seeks to examine how the perception of information manipulation may influence one’s evaluation of an e-Doctor. There are two primary aims of this study: a) to replicate DeAndrea and Carpenter’s test of warranting theory on e-Doctor in the era of e-Health; b) to verify the role of three information manipulation approaches, including modification control, dissemination control, and source obfuscation control, in one’s appraisal of an e- Doctor. An online experiment was conducted in 2016. Results revealed that there was a negative correlation between perception of information manipulation likelihood and evaluation of e-Doctor. However, there was no significant difference between high-level control and low- level control groups in the source obfuscation control model. Other influential factors towards the evaluation of an e-Doctor were also discussed.