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The aim of our paper is to propose a whole-person model of stress and wellness. Guided by the theoretical underpinnings of Boss’s (2002) ABC-X stress model and Scarduzio and Geist-Martin’s (2016) whole-person approach, we critique and adapt these frameworks to explain the complexities of stress and wellness processes at multiple communication levels. By analyzing data from a pediatric hospital, we will demonstrate how researchers can examine employees’ stress and coping behaviors, as well as the effectiveness of an organization’s physical, psychological, social, and/or spiritual resources on employees’ coping behaviors. It is through an evaluation of these processual components that researchers can gain a more complete understanding of how, and to what effect, organizations communicate a whole-person status to employees.