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This study examines links between knowledge, agency, and responsive literacy instruction as a preservice teacher (PST) provided one-to-one literacy instruction. Findings illustrate a dynamic interplay between PST knowledge, agency, and responsiveness. Given few teacher education programs sufficiently prepare PSTs for enacting responsive instruction amid a sociopolitical context designed to prevent responsive instruction, findings offer insight into how to prepare PSTs to enact practices that ultimately result in equitable literacy instruction and outcomes for all students.