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Two studies were conducted to examine (1) individuals general perception on stigma regarding STDs, and (2) the effectiveness of the Mercks Gardasil advertisement. People attributed with more controllability and responsibility, were likely to receive more blame and stigma, resulting low communication efficacy. Study 2 found by omitting the fact concerning the sexually transmitted nature of HPV, the actual Gardasil advertisement appeared to be benefitted from reducing stigma, but compromised its effect inducing health threat.