Biography

Dr. Terry Jernigan is Professor of Cognitive Science, Psychiatry, and Radiology, and Director, Center for Human Development at the University of California, San Diego. For over 30 years, she has studied the human brain using noninvasive imaging. This work has focused on brain development and aging, neurodevelopmental disorders, neuropsychiatric and substance use disorders, and neurodegenerative disorders. For the last decade her central research interest has been the developing human mind and brain, with a focus on the dynamic neurodevelopmental processes that give rise to human individuality—and on how these processes are affected by experience, substance exposure, genetic variation, and other factors. She is Co-Director of the Coordinating Center for the ABCD Study. She has served on the National Advisory Council on Drug Abuse and the Council of Councils of the National Institutes of Health, and she currently serves on the scientific advisory boards of several research organizations in the United States and Europe.

Dr. Hugh Garavan is a Professor in the Department of Psychiatry at the University of Vermont. He received his PhD in Cognitive Psychology from Bowling Green State University in Ohio and completed postdoctoral fellowships at Cornell University and the Medical College of Wisconsin. His research uses structural and functional neuroimaging to study cognitive control and reward processes with a particular interest in how functional changes in these systems may contribute to addiction. In addition to studying current abusers of numerous drugs, he has researched the importance of cognitive control systems for successful drug abstinence. His primary research focus of the last few years has been risk factors for drug use during adolescence and he is a co-investigator on the IMAGEN project, a longitudinal neuroimaging-genetic study of over 2,000 teens. He is a site PI and Associate Director of the Adolescent Brain Cognitive Development study. Dr. Garavan is a member of several professional societies, has served as secretary for the Organization for Human Brain Mapping, is a standing member of the NPAS study section, has been a reviewer for the NSF, several European grant-giving agencies, and over 50 journals. He has published almost 250 papers in the fields of cognitive neuroscience and addiction.

Dr. Thompson earned his Ph.D. in Statistics from Rutgers University in 2003, with a focus on statistical methods for longitudinal data analysis. He was appointed Assistant Professor of Statistics and Psychiatry at the University of Pittsburgh in 2005, where he received a five year NIH K25 Career Development Award to develop novel methods for studying co-variation in brain function and depression. Dr. Thompson joined the UCSD Department of Psychiatry in 2008. His current work involves Bayesian semi-parametric and mixture models with applications to (i) improving effect size estimation, replication, and prediction in genome-wide association studies, (ii) predicting onset of illness from multivariate biomarker trajectories, (iii) applications of functional data analysis to functional MRI data. Dr. Thompson is currently the Director of Statistics for the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) and Associate Director of the Data Analysis and Informatics Core for the Adolescent Brain and Cognitive Development Study.

3-002 - ABCD Study

Session Type: Invited Symposium

Abstract

The Adolescent Brain Cognitive Development (ABCD) Study is a large-scale, multi-site study of health and behavior focusing on the developing brain, and on factors that influence adolescent trajectories of cognitive, intellectual, and social-emotional development. The goal is to enroll well over 10,000 children at 9 or 10 years of age, at 21 sites nationwide, and follow them for 10 years. The ABCD consortium has embraced an open-science model and an aggressive timeline for sharing, not only the terabytes of data collected, but the computational workflows used to produce them, and some novel computational tools that the scientific community can use to explore and model them. Three members of the ABCD team will provide additional information about the ABCD Resource: Terry Jernigan, Co-Director of the Coordinating Center, will give an overview of the ABCD study, the cohort and data collected, and the data sharing policies and timelines; Hugh Garavan, Associate Director of the Coordinating Center and U. Vermont site PI, will describe in more detail the functional imaging data and some early results emerging from the study; and Wes Thompson, Associate Director for Biostatistics (of the ABCD Data Analysis and Informatics Center) will describe a powerful new tool under development in ABCD to help users to optimize their analyses of ABCD data.

Sub Unit

• Invited Program

Chair

• Adriene Beltz, University of Michigan

Individual Presentations

• ABCD & The Open Science Model - Presenting Author: Terry Jernigan, University of California, San Diego

• Brain Function in the Pre-Adolescent Brain: Results from the ABCD Study - Presenting Author: Hugh Garavan, University of Vermont

• ABCD Data Exploration and Analysis Portal: Enabling Open and Reproducible Science - Presenting Author: Wesley Thompson, University of California, San Diego