2-081 - Interpersonal Stress and Adolescent Internalizing Psychopathology: The Role of Neurobiological Regulation

Session Type: Paper Symposium

Integrative Statement

It is well-established that exposure to interpersonal stressors often precedes the development of internalizing psychopathology, especially during adolescence. In the last decade, increasing research attention has been given to investigating the biological processes linking interpersonal stress to internalizing psychopathology. However, little is known about how neurobiological regulation occurring at multiple levels is implicated in the development of adolescent internalizing psychopathology. Collectively, the papers in this symposium offer important advances in this research area, by examining regulation following exposure to interpersonal stress at the neural (Paper1), physiological (Paper 2), genetic (Paper 3) and molecular (Paper 4) level. Notably, each of these papers addresses this issue by adopting state-of-the-art methodologies that combine longitudinal designs, in vivo laboratory tasks and interview assessments.
Paper1 uses functional magnetic resonance imaging to reveal that adolescents who are exposed to child maltreatment, an extremely severe social stressor, show atypical neural responses to an emotion regulation task, which, in turn, are associated with heightened risk for internalizing psychopathology. Paper 2 employs a laboratory social stressor to examine the interplay between HPA-axis stress responses and approach-avoidance motivation in the longitudinal prediction of adolescent depressive symptoms. Paper 3 and 4 examine whether the risk for developing depressive symptoms among adolescents exposed to interpersonal life stressors is moderated by genetic variation in the μ-opioid receptor gene (OPRM1) (Paper 3) and social stress-induced inflammatory responses (Paper 4).
Altogether, findings from these papers provide a more comprehensive picture about the role of neurobiological regulation in the association between interpersonal stress and internalizing psychopathology.

Sub Unit

• Biological Processes

Chair

• Matteo Giletta, Tilburg University

Individual Presentations

• Child Maltreatment and Neural Function in Systems Underlying Emotion Regulation - Presenting Author: Kate McLaughlin, University of Washington; Margaret A. Sheridan, Harvard University

• Joint Contribution of HPA Axis Regulation and Motivation to Adolescent Depression - Presenting Author: Karen D. Rudolph, University of Illinois, Urbana-Champaign; Wendy Troop-Gordon, North Dakota State University

• Endogenous Opioid System Influences Depressive Reactions to Socially Painful Targeted Rejection Life Events in Adolescence - Presenting Author: George M. Slavich, University of California, Los Angeles; Molly A. Tartter, University of California, Los Angeles; Patty Brennan, Emory University; Costance Hammen, University of California, Los Angeles

• Social Stress-Induced Inflammatory Responses Moderate the Effect of Interpersonal Life Stress on Depression in Adolescence - Presenting Author: Matteo Giletta, Tilburg University; George M. Slavich, University of California, Los Angeles; Karen D. Rudolph, University of Illinois, Urbana-Champaign; Paul David Hastings, U California, Davis; Matthew K. Nock, Department of Psychology, Harvard University, Cambridge, MA; Sarah W Helms, University of North Carolina, Chapel Hill; Mitchell J Prinstein, Univ of North Carolina - Chapel Hill