3-039 - Multi-System Physiological Calibration and Affective Experience in at Risk Youths: Focus on HPA-HPG Dual Axes Coupling

Session Type: Paper Symposium

Integrative Statement

Social and economic disparities beginning with the experience of early life stress have been shown to lead individuals on paths toward increased health risks later in life. Both hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes are responsive to environmental stress. Moreover, emerging developmental studies suggest that positive HPA-HPG coupling is adaptive and can help adolescents navigate their increasingly complex social milieu. The four talks within this symposium converge on empirical evidence documenting HPA-HPG coupling during adolescence. Based on evidence showing accelerated maturation of brain and endocrine system dynamics in youths exposed to a broad conception of early adversity, we contend further study of the contexts under which multi-system physiological coupling is representative of typical versus atypical development is critical. These four talks go beyond characterizing dual axes coupling, investigating whether such coupling is linked with early adversity and or psychopathology. We studied 6 independent samples, examining youths who are at risk for internalizing disorders, at risk for externalizing disorders, exposed to trauma and or maltreatment, and those incarcerated, representing diverse risk severity. We view interconnected physiological circuitry as responsive to affective input in an experience expectant manner whereby increased affective exposure accelerate the tuning and maturation of multiple systems. We propose a developmental approach that emphasizes individual differences in exposure to early adversity and risk for psychopathology as well as the importance for multi-time scale comparisons for understanding complex HPA-HPG axes dynamic systems interplay.

Sub Unit

• Biological Processes

Chairs

• Georges Han, University of California, Davis

• Andrew Dismukes, Iowa State University

Individual Presentations

• Dual axis coupling of HPA-HPG hormones across multiple time-scales serve as biomarkers of positive psychosocial development - Presenting Author: Kristine Marceau, Brown University; Elizabeth A. Shirtcliff, Human Development & Family Studies; Bonnie Klimes-Dougan, University of Minnesota; Carolyn Zahn-Waxler, University of Wisconsin; Paul David Hastings, U California, Davis

• Adolescents' Typical and Atypical Dual Axes Neuroendocrine Coupling in Response to Anxiety and Anger Inductions - Presenting Author: Georges Han, University of California, Davis; Jonas G Miller, University of California, Davis; Pamela M Cole, Penn State Univ; Carolyn Zahn-Waxler, University of Wisconsin; Paul David Hastings, U California, Davis

• Dual-axis hormonal covariation in adolescence and the moderating influence of prior trauma and aversive maternal parenting - Presenting Author: Julian Guy Simmons, University of Melbourne; Michelle L. Byrne, Univ of Oregon; Orli S. Schwartz, University of Melbourne; Sarah Lauren Whittle, University of Melbourne; Lisa Sheeber, Oregon Research Institute; George J Youssef, Monash University; Nicholas Allen, University of Oregon

• Temporally and Contextually Dependent Coupling of the HPA and HPG Axes - Presenting Author: Andrew Dismukes, Iowa State University; Elizabeth A. Shirtcliff, Human Development & Family Studies