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1-128 - Trajectories of Brain Development Underlying Features of Autism in At-risk Infants
Thu, March 19, 2:10 to 3:40pm, Marriott, Floor: Level 4, Room 401/402/403Session Type: Paper Symposium
Integrative Statement
Autism spectrum disorder (ASD) is a neurodevelopmental disorder behaviorally characterized by deficits in social interaction, communication, and the presence of repetitive and stereotyped behaviors. Prospective studies of infants at high-risk for ASD report that the defining behavioral features are not evident until 12 months of age (Brian et al., 2008; Zwaigenbaum et al., 2005; Sullivan et al., 2007; Wolff et al., 2014), however magnetic resonance imaging studies have reported aberrant brain development early in the first year of life (Wolff et al., 2012; Elison et al., 2013; Shen et al., 2013), suggesting that early neurobiological changes may precede, and impact, the emergence of core behavioral deficits of ASD. In the current symposium we highlight recent research that aims to understand developmental processes affecting ASD by tracing neural development throughout infancy. Paper 1 outlines a longitudinal examination of brain tissue volumes from 6-24 months in a sample of infants who are later diagnosed with ASD. Paper 2 utilizes diffusion tensor imaging to relate cerebellar white matter fiber tract development to the sensory features of ASD. Paper 3 presents longitudinal data showing increased volume of cerebrospinal fluid (CSF) at 6 months of age in infants who are later diagnosed with ASD. Together, this symposium presents data on a unique, large sample of infants at high familial risk for ASD with neuroimaging data. This symposium will address issues of early, longitudinal brain and brain-behavior development as ASD unfolds during infancy as well as the possibility of early biomarkers predicting later risk of ASD.
Sub Unit
Chair
Discussant
Individual Presentations
Patterns of Brain Volume Differences in Infants at High Risk for Autism Spectrum Disorder - Presenting Author: Heather Cody Hazlett, University of North Carolina, Chapel Hill; Hongbin Gu, Department of Psychiatry, University of North Carolina-Chapel Hill; Martin Styner, Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA; Kelly Botteron, Department of Psychiatry, Washington University; Stephen Dager; Annette Mercer Estes, University of Washington; Alan Evans, McGill University; Vlad Fonov, Montreal Neurological Institute, McGill University, Montreal, QB, Canada; Guido Gerig, Scientific Computing and Imaging Institute, University of Utah; Penelope Kostopoulos, McGill University; Robert C McKinstry, Dept. of Radiology, Washington University; Juhi Pandey, Center for Autism Research, Children's Hospital of Philadelphia; Sarah Paterson, Temple University; John Pruett, Department of Psychiatry, Washington University; Robert Schultz, (1) Center for Autism Research, The Children's Hospital of Philadelphia, Philadelphia, PA, (2) Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Lonnie Zwaigenbaum, University of Alberta; Joseph Piven, University of North Carolina (System)
A Diffusion Tensor Imaging Study of Emerging Sensory Features in Toddlers with Autism - Presenting Author: Jason J Wolff, University of Minnesota; Guido Gerig, Scientific Computing and Imaging Institute, University of Utah; Martin Styner, Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA; Meghan Swanson, University of North Carolina, Chapel Hill; Jed T. Elison, University of Minnesota; Annette Mercer Estes, University of Washington; Lisa Flake, Department of Psychiatry, School of Medicine, Washington University in St. Louis; Cheryl Klohr, Department of Psychiatry, School of Medicine, Washington University in St. Louis; Penelope Kostopoulos, McGill University; Juhi Pandey, Center for Autism Research, Children's Hospital of Philadelphia; Sarah Paterson, Temple University; Lonnie Zwaigenbaum, University of Alberta; Joseph Piven, University of North Carolina (System)
Infants Who Develop Autism Spectrum Disorder Have Excessive External Cerebrospinal Fluid at 6 Months of Age - Presenting Author: Mark D. Shen, Univ of North Carolina - Chapel Hill; SunHyung Kim, Dept. of Psychiatry, University of North Carolina at Chapel Hill; Hongbin Gu, Department of Psychiatry, University of North Carolina-Chapel Hill; Heather Cody Hazlett, University of North Carolina, Chapel Hill; Christine Nordahl, MIND Institute and Department of Psychiatry & Behavioral Sciences UC Davis; Robert C McKinstry, Dept. of Radiology, Washington University; Dennis Shaw, Department of Radiology, University of Washington; Guido Gerig, Scientific Computing and Imaging Institute, University of Utah; Stephen Dager; Kelly Botteron, Department of Psychiatry, Washington University; Robert Schultz, (1) Center for Autism Research, The Children's Hospital of Philadelphia, Philadelphia, PA, (2) Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Sarah Paterson, Temple University; Alan Evans, McGill University; Annette Mercer Estes, University of Washington; Lonnie Zwaigenbaum, University of Alberta; Martin Styner, Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA; David G Amaral, MIND Institute and Department of Psychiatry & Behavioral Sciences UC Davis; Joseph Piven, University of North Carolina (System)