3-169 - Gene-Environment Interactions and Adolescent Antisocial Behavior, Social Anxiety, and Depressive Symptoms

Session Type: Paper Session

Integrative Statement

This paper session focuses on gene-environment interactions as determinants of adolescent psychopathology using longitudinal designs and single gene or clusters of genetic SNPs/polygenic scores. The first paper uses the Pittsburgh Girls Study sample to examine prospective associations between the gene-environment interaction of high- versus low-activity monoamine oxidase-A (MAOA) and childhood maltreatment and later adolescent/young adult antisocial behavior and mediation by adolescent emotion reactivity. The second paper uses the National Longitudinal Study of Adolescent to Adult Health to examine the gene-environment interaction between multigenic risk scores from polymorphisms in dopamine and serotonin genes and school connectedness on developmental pathways of antisocial behavior. The third paper examines risk for social anxiety symptoms in adolescence using the gene-environment interaction between polygenic scores of adolescent genetic liability/susceptibility regarding the oxytocin system and non-supportive social contexts in an ongoing longitudinal study. The fourth paper examines corticotrophin-releasing hormone receptor 1 gene (CRHR1) related to hypothalamic-pituitary-adrenal axis functioning as a genetic moderator of intervention effects on trajectories of depressive symptoms within a randomized controlled trial of a cognitive behavioral prevention program for adolescents at risk for depression.

Sub Unit

• Developmental Psychopathology

Chair

• Leslie Leve, University of Oregon

Individual Presentations

• MAOA, childhood maltreatment and antisocial behavior in females: Emotional reactivity as a potential mediator - Presenting Author: Amy L Byrd, University of Pittsburgh School of Medicine; Stephen D. Manuck, University of Pittsburgh; Samuel W. Hawes, Florida International University; Vishwajit Nimgaonkar, University of Pittsburgh Medical Center; Kodavali V. Chowdari, University of Pittsburgh Medical Center; Alison Hipwell, University of Pittsburgh; Kathryn Keenan, University of Chicago; Stephanie Stepp, University of Pittsburgh

• Interplay between Multigenic and Environmental Influences on Adolescent to Adult Pathways of Antisocial Behaviors - Presenting Author: James Li, University of Wisconsin-Madison

• Adolescent Social Anxiety Symptom Development: A Gene-Environment Interaction Study Using a Novel Polygenic Approach - Presenting Author: Stefanie A. Nelemans, KU Leuven; Wim H.J. Meeus, Utrecht University & Tilburg University; Susan J. T. Branje, Utrecht University; Luc Goossens, KU Leuven

• Genetic Moderation of the Impact of a Prevention of Depression Program on Adolescents’ Depressive Symptoms - Presenting Author: Kalsea J Koss, Princeton University; Judy Garber, Vanderbilt University; David Brent, University of Pittsburgh; Gregory Clarke, Center for Health Research, Kaiser Permanente Northwest; William Beardslee, Boston Children's Hospital; V. Robin Weersing, San Diego State University; Steven D. Hollon, Vanderbilt University; Tracy R. G. Gladstone, Wellesley Centers for Women, Wellesley College; Nadine Melhem, University of Pittsburgh