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3-098 - Variability within neurodevelopmental disorders: Insights from developmental studies
Sat, March 23, 9:45 to 11:15am, Hilton Baltimore, Floor: Level 1, LatrobeSession Type: Paper Symposium
Integrative Statement
Neurodevelopmental disorders, such as Down syndrome, Fragile X, and Attention Deficit Hyperactivity Disorder (ADHD), show large variability in terms of phenotypic outcomes within a disorder group as well as overlap across different disorders. For many decades, this variability has been considered “noise” or a nuisance variable. However, using examples from both cross-sectional studies and longitudinal studies, the current symposium discusses how examination of this variance can provide novel insight into the factors that can protect or impact phenotypical outcomes.
The first paper examines variance over developmental time and explores early language development in infants with Down syndrome longitudinally in order to verify how early abilities may be related to adult phenotypic outcomes. The second paper focuses on individual differences within a group to determine the impact of ASD and ADHD symptomatology on variability within the language abilities of children with Fragile X longitudinally. In the third paper motor abilities in a cross-sectional sample of children with ADHD are explored in order to examine whether motor difficulties are a core characteristic of ADHD or a developmental outcome of ADHD symptomatology. The fourth paper considers how genetic variance might explain variability within the cognitive outcomes of participants with Down syndrome across the life span.
Together these papers demonstrate that taking a developmental approach provides novel insight into how factors which present early in development impact variability and outcomes later in development. A better understanding of this variability will allow for better theoretical understanding as well as interventions.
Sub Unit
Chair
Individual Presentations
How do symptoms of ASD and ADHD predict language and communication abilities in Fragile X Syndrome? - Presenting Author: Elise Ng-Cordell, University of Oxford; Non-Presenting Author: Jacalyn Guy, University of Oxford; Non-Presenting Author: April Philpott, Monash University; Non-Presenting Author: Victoria Cole, King's College London; Non-Presenting Author: Elena Longhi, UCL; Non-Presenting Author: Kim Cornish, Monash University; Non-Presenting Author: Annette Karmiloff-Smith, Birkbeck, University of London; Non-Presenting Author: Gaia Scerif, Oxford University
Motor impairment in Attention Deficit Hyperactivity Disorder (ADHD); part of the ADHD phenotype? - Presenting Author: Emily K. Farran, University College London; Non-Presenting Author: Aislinn Bowler, UCL; Non-Presenting Author: Annette Karmiloff-Smith, Birkbeck, University of London; Non-Presenting Author: Hana D'Souza, University of Cambridge & Birkbeck, University of London; Non-Presenting Author: Leighanne Amy Mayall, University College London; Non-Presenting Author: Emma Sumner, UCL Institute of Education; Non-Presenting Author: Dan Brady, University of Surrey; Non-Presenting Author: Elisabeth L Hill, Goldsmiths, University of London
From protection to risk: Differential effects of the APOE e4 allele across the lifespan in Down syndrome - Presenting Author: Hana D'Souza, University of Cambridge & Birkbeck, University of London; Non-Presenting Author: Luke Mason, Birkbeck, University of London; Non-Presenting Author: Emma Meaburn, Birkbeck, University of London; Non-Presenting Author: Kin Y Mok, UCL; Non-Presenting Author: John Hardy, UCL; Non-Presenting Author: Annette Karmiloff-Smith, Birkbeck, University of London; Non-Presenting Author: Denis Mareschal, Birkbeck, University of London; Non-Presenting Author: Michael S. C. Thomas, University of London