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1-125 - Genetically-Informed Studies of Adolescent Substance Use and Psychopathology
Thu, March 21, 2:15 to 3:45pm, Baltimore Convention Center, Floor: Level 3, Room 321Session Type: Paper Symposium
Integrative Statement
Adolescence serves as a critical window for development, with rapid changes in both physical and mental health. Moreover, it is well known that, the transition from early adolescence into early adulthood is commonly characterized by the initiation of drug use and emergence of psychopathology. Twin and family studies consistently stress the importance of both genetics and environmental factors as contributions to these types of problematic behaviors.
Therefore, mitigating substance use and mental health problems during this period necessitates a detailed, developmental, understanding of such risk/protective factors underlying these outcomes. Genetically-informed studies of development take advantage of molecular genetic data and/or family data, to tease apart and identify specific genetic and importantly, environmental liabilities. Likewise, the designs of these studies afford improved causal, which is imperative for effective intervention/prevention efforts. This symposium features a series of papers focused on utilizing genetically-informed designs to better elucidate adolescent psychopathology and problematic substance use. The first study, of adolescence, examined associations between polygenic risk scores (PGRS), developed from genome-wide studies of antisocial behavior, and correlated phenotypes such as impulsivity, oppositional defiant disorder, and conduct disorder. The second paper examined the interplay between a conduct disorder PGRS and community disadvantage in predicting adolescent marijuana use. Finally, the third paper used data from independent, longitudinal twin studies, to examine genetic and environmental contributions to the initiation and course of marijuana use as well as mental health outcomes throughout adolescence. Each study provides evidence for overlapping genetic and environmental risk for both substance use and psychopathology.
Sub Unit
Chair
Discussant
Individual Presentations
Genetic and environmental contributions to marijuana use development: Twin analyses across three independent data sets - Presenting Author: Eric Lee Thibodeau, Department of Psychology, University of Minnesota, Minneapolis, MN; Non-Presenting Author: Stephanie Zellers, University of Minnesota; Non-Presenting Author: Frank D Mann, University of Minnesota; Non-Presenting Author: Irene Elkins, University of Minnesota; Non-Presenting Author: Robin P Corley, University of Colorado; Non-Presenting Author: John Hewitt, University of Colorado; Non-Presenting Author: Michael Stallings, University of Colorado; Non-Presenting Author: Robert Krueger, University of Minnesota; Non-Presenting Author: Robert Iacono, University of Minnesota; Non-Presenting Author: Matt McGue, University of Minnesota; Non-Presenting Author: Scott Vrieze, University of Minnesota
Association between Antisocial Behavior Polygenic Scores and Adolescent Subclinical and Clinical Externalizing Behaviors - Presenting Author: Sally I-Chun Kuo, Virginia Commonwealth University; Non-Presenting Author: Jessica Salvatore, Virginia Commonwealth University; Non-Presenting Author: Danielle M. Dick, Virginia Commonwealth University
The Interplay between a Conduct Disorder Polygenic Risk Score and Community Disadvantage in Predicting Marijuana Use Disorders - Presenting Author: Jill A. Rabinowitz, Johns Hopkins University; Non-Presenting Author: Rashelle Jean Musci, Johns Hopkins Bloomberg School of Public Health; Non-Presenting Author: Adam Milam, Johns Hopkins University; Non-Presenting Author: Kelly Benke, Johns Hopkins University; Non-Presenting Author: Danielle Y. Sisto, Johns Hopkins University; Non-Presenting Author: Nicholas S. Lalongo, Johns Hopkins University; Non-Presenting Author: Brion S. Maher, Johns Hopkins University; Non-Presenting Author: George Uhl, New Mexico VA HealthCare System