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Luke Hyde focuses on developmental psychopathology, risk, and resilience. His research has focused on several themes: the development of antisocial behavior with a focus on the roles of parents and neighborhoods, the development of callous-unemotional traits and psychopathy, the effects of poverty on families and youth, gene by environment interaction and behavioral genetics, examining brain activity as a predictor of psychopathology, and examining the effects of adversity on brain and behavioral development.