Functional brain predictors and correlates of suicidal ideation and non-suicidal self-injury in adolescents

Session Type: Paper Symposium

Abstract

Suicide is the second leading cause of death among adolescents and young adults in the U.S. Suicidal ideation (SI) and non-suicidal self-injury (NSSI) are prevalent, and often co-occurring but distinct phenomenon that each incur risk for death by suicide. However, very little is known about the neurobiological substrates of SI and NSSI in adolescents. Focusing on multimodal functional MRI methods, this symposium aims to advance our understanding of the neurobiological markers commonly related to self-referential processing, emotion regulation, and future planning that are associated with SI and NSSI in youth. First, we will present data from a large nationally representative sample of 9–10-year-old children on associations between SI and intrinsic connectivity and task-elicited activation to emotional stimuli in the cortical default mode (DMN) and salience networks (SN) compared to children without SI. Second, we will describe results from a community sample of children and adolescents where machine learning algorithms applied to whole brain graph theoretical metrics predicted severity of SI 4 years later. Third, we will present data from a sample of adolescents and emerging adults with NSSI showing that increased connectivity patterns in regions of the DMN and SN are associated with higher scores on a dimensional measure of suicide risk. Finally, we will describe shared and unique patterns among subnetworks in the DMN and SN associated with SI and/or NSSI in a sample of adolescents with depression. Together, these findings highlight potential neurobiological underpinnings of suicide risk that may inform intervention efforts.

Sub Unit

• Developmental Psychopathology

Chairs

• Andrea Wiglesworth, University of Minnesota - Twin Cities

• Tiffany C Ho, University of California - San Francisco

Individual Presentations

• Salience and default mode networks in 9 and 10-year-olds with and without suicide ideation - Presenting Author: Andrea Wiglesworth, University of Minnesota - Twin Cities; Non-Presenting Author: Conner A Falke, University of Minnesota - Twin Cities; Non-Presenting Author: Mark B. Fiecas, University of Minnesota; Non-Presenting Author: Monica Marie Luciana, University of Minnesota–Twin Cities; Non-Presenting Author: Kathryn Cullen, University of Minnesota; Non-Presenting Author: Bonnie Klimes-Dougan, University of Minnesota - Twin Cities

• Connectivity findings associated with suicidality in young people with non-suicidal self-injury - Presenting Author: Mindy Westlund Schreiner, University of Utah; Non-Presenting Author: Bonnie Klimes-Dougan, University of Minnesota - Twin Cities; Non-Presenting Author: Bryon Mueller, University of Minnesota; Non-Presenting Author: Kathryn Cullen, University of Minnesota

• Default Mode and Salience Network Alterations in Suicidal and Non-Suicidal Self-Injurious Thoughts and Behaviors in Adolescents with Depression - Presenting Author: Tiffany C Ho, University of California - San Francisco; Non-Presenting Author: Johanna C Walker, Stanford University; Non-Presenting Author: Giana I Teresi, Stanford University; Non-Presenting Author: Artenisa Kulla, Stanford University; Non-Presenting Author: Jaclyn Schwartz Kirshenbaum, Columbia University; Non-Presenting Author: Anthony J. Gifuni; Non-Presenting Author: Manpreet K Singh, Stanford University; Non-Presenting Author: Ian Gotlib, Stanford University