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The Prenatal Environment and Early Experiences: Neurodevelopmental Consequences of Stress in Infants and Young Children
Wed, April 7, 4:20 to 5:50pm EDT (4:20 to 5:50pm EDT), VirtualSession Type: Paper Symposium
Abstract
Early-life stress exposures can dramatically influence trajectories for development by differentially altering neurodevelopment, immune response, and the hypothalamic-pituitary-adrenal axis. The specific concurrent and temporally proximal associations between stress and alterations in these biological systems, however, is poorly understood across early life. Using multiple biological measures, assessments of multiple domains of stress, and multivariate statistical methods, this symposium examines the effects of exposure to early stressors across neonatal, infant, and child populations. The first talk examines how features of the prenatal environment (e.g., maternal health, socioeconomic status, and life history) influence the offspring brain via maternal-placental-fetal biology using multivariate canonical correlation analysis. The second talk investigates the association between prenatal maternal immune activation and alterations in neonatal white matter structure and metabolites. The third talk provides evidence for associations between maternal prenatal depressive symptoms—which are often precipitated or worsened by stress—and hippocampal volumes in one-month-old infants. The final talk in this symposium uses machine learning to investigate the effects of early-life threatening experiences on structural brain connectivity at a cognitive network level in young children. This research spans across multiple developmental timepoints to further elucidate how variations in the early life environment alter trajectories of biological development. Taken together, this work highlights the necessity for sophisticated methods—tailored to young populations—in order to characterize the effects of stress across early life. Understanding how stress differentially disrupts development during the most plastic period in biological development is critical for informing policy aimed at improving both maternal and offspring well-being.
Sub Unit
Chair
Individual Presentations
Modeling Biological Pathways by Which the Prenatal Environment Influences Offspring Neurodevelopment Using a Multivariate Approach - Presenting Author: Madeleine Allen, Oregon Health & Science University (OHSU); Non-Presenting Author: Eric Feczko, University of Minnesota; Non-Presenting Author: Jerod M. Rasmussen, University of California, Irvine; Non-Presenting Author: Sonja Entringer, Charité University of Medicine Berlin; Non-Presenting Author: Pathik D. Wadhwa, University of California, Irvine; Non-Presenting Author: Claudia Buss, Charité University of Medicine Berlin; Non-Presenting Author: Damien A. Fair, University of Minnesota - Twin Cities; Non-Presenting Author: Alice M. Graham, Oregon Health and Science University
Prenatal Maternal Immune Activation is Associated With Brain Microstructural Tissue Organization and Metabolites in Neonates - Presenting Author: Marisa N. Spann, Columbia University; Non-Presenting Author: Catherine Monk, Columbia University Irving Medical Center; Non-Presenting Author: Ravi Bansal, Children’s Hospital Los Angeles; Non-Presenting Author: Bradley S. Peterson, Children’s Hospital Los Angeles
Prenatal Depressive Symptoms are Associated With Smaller Infant Offspring Hippocampal Volume - Presenting Author: Kathryn L. Humphreys, Vanderbilt University; Non-Presenting Author: M. Catalina Camacho, Washington University in St. Louis; Non-Presenting Author: Vikas Dodda, Vanderbilt University; Non-Presenting Author: Sydney Takemoto, Vanderbilt University; Non-Presenting Author: Marissa C. Roth, Vanderbilt University
Threatening and Interpersonally Proximal Experiences are Associated With Increased Structural Network Connectivity in Young Children - Presenting Author: Jenna H. Chin, University of Denver; Non-Presenting Author: M. Catalina Camacho, Washington University in St. Louis; Non-Presenting Author: Kathryn L. Humphreys, Vanderbilt University; Non-Presenting Author: Caroline P. Hoyniak, Washington University in St. Louis; Non-Presenting Author: Susan B. Perlman, Washington University in St. Louis