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Novel Methodological Approaches for Advancing Study of the Intergenerational Transmission of Depression

Thu, March 23, 3:15 to 4:45pm, Salt Palace Convention Center, Floor: 3, Meeting Room 355 B

Session Type: Paper Symposium

Abstract

A substantial literature indicates that maternal depression is associated with increased risk of depression in offspring. Influential models suggest that mechanisms of transmission include differences in parenting behaviors, mother-infant interactions, and neonatal neurobiology. However, important questions in this area remain, including: (1) whether depression and parenting behaviors are causally related; (2) how timing and measurement affect these associations; (3) how depressive symptoms affect real-time unfolding of interactions within dyads; and (4) whether observed differences in neurobiology mediate later offspring functioning. In this symposium, we employ a series of novel methodologies to examine these questions and advance our understanding of how depression is transmitted across generations. The first two papers examine nuances in the well-established association between depression and parenting. Specifically, the first paper uses a statistical approach from the causal inference literature to examine how timing and chronicity of postpartum depression affect sensitive parenting after balancing across an array of potential confounds. The second paper examines how distortions about parenting competence predict within-person changes in maternal depression. The third paper, which considers both the between- and within-person levels, examines how the dynamics of mother-infant interactions differ according to maternal depression. Finally, the fourth paper uses multiple levels of analysis to examine whether differences in neonatal brain development link maternal adverse experiences with infant negative emotionality. Collectively, these papers, each of which focuses on infancy as an important sensitive period, demonstrate how recent methodological advances can be leveraged to advance our understanding of the mechanisms underlying the intergenerational transmission of depression.

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