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This paper is informed by short-term ethnographic fieldwork in the Antarctic Peninsula with Chilean microbiologists engaged in the bioprospecting of extremophiles, to account for how extremophile organisms are made part of a market-driven search for bioactive components in areas highly sensitive to geopolitics at the same time as they become meaningful as proxies for extraterrestrial life. The paper combines analysis, description, and fieldwork material, tracing the relational trajectories of Antarctica and outer space in very general terms and then discussing the intricacies of bioprospecting in Antarctica, where the question of who owns the microbial diversity existing outside of national territories remains ambiguous and contested.