Photolytic cleavage of N-acyl-7-nitroindolines on nanopartices and in metal organic frameworks

• In Event: Poster Presentation and Judging for: Biomedical; Cell & Molecular Biology; Chemistry & Biochemistry; Marine Science; Systematics & Evolutionary Biology.
  In Poster Session: Chemistry & Biochemistry Poster Session

Abstract

The photolytic cleavage of N-acyl-7-nitroindolines in solution is well known, but their behavior on solid surfaces is much less studied. For the first time the immobilization of a cysteine-5-bromo-7-nitroidoline derivative to the surface of gold nanorods, and the subsequent photorelease of 5-bromo-7-nitroindoline into the solution triggered by UV light is observed. This system could potentially be useful for the controlled light-induced delivery of compounds by a photo-release mechanism in living cells. We also demonstrate that N-acetyl-5-bromo-7-nitroindoline can be non-covalently absorbed by metal organic frameworks (MOFs), and photolytically cleaved inside of the MOF’s cavities. This photochemistry allows the study of host-guest chemistry in MOFs. The synthesis and characterization of the photoreactive compounds, nano rods, and the MOFs used in this study will also be presented.

Author

• Karen Liliana Castaneda, University of Texas El Paso