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At the heart of modern manufacturing facilities, multistage manufacturing systems (MMSs) involve a complex network of interconnected stages of operations to fabricate a product. MMS inefficiency is primarily caused by disruptions that occur at various workstations in a system. Due to the interdependence among workstations, one disruption might disrupt other station(s) and even a system stoppage, and another disruption might be compensated by inventory buffers and generate no impact on the system output. Understanding the economic consequence of individual disruptions is critical for shop-floor planning and control purposes, including bottleneck identification, performance evaluation, and capital budgeting decisions. Motivated by real-world challenges faced by a large automobile manufacturer regarding how to optimize its system improvement activities, we propose an approach to measure the cost of disruptions by allocating the system-wide production-volume variance benchmarked against a disruption-free condition. We also conduct a simulated case study based on field data from an automobile assembly line to show that our approach is useful to identify system “cost bottlenecks” and to assist system improvement activities.