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Following PRISMA guidelines, we conducted a systematic literature review to uncover, analyze, and present design characteristics of virtual reality systems that have been developed as training tools for individuals with autism. Databases searched for this review were Web of Science, PubMed, Scopus, IEEE Xplore, ERIC, and Google Scholar. A total of 82 articles across 49 projects were analyzed. Findings from this literature review will be discussed as well as limitations and directions for future research.