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The present paper reports the results of a meta-analysis of instructional strategies that employ concrete manipulatives during mathematics instruction. A systematic search of the literature identified 60 studies examining the use of concrete manipulatives during mathematics instruction. Results of the meta-analysis revealed a significant positive effect size, as measured by Cohen’s d, in favor of manipulatives on measures of student retention and problem solving; yet results for learning as measured by transfer and justification outcome measures were inconclusive. Furthermore, a descriptive analysis of study characteristics indicated that the majority of the summarized studies had methodological weaknesses that limit the ability to make causal claims.