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The present study addressed three issues that pertain to the ways in which students form their perceptions of efficacy in science. The author sought to: (1) explore whether there are subpopulations of middle school and high school students (n=1225) that arise when grouped by the four hypothesized sources of self-efficacy; (2) examine whether there are group differences among these latent groups based on gender, grade level, and gifted status; and (3) explore whether students’ beliefs about the plasticity of their science ability were related to latent group membership. Four latent groups emerged, which exhibited differences in science self-efficacy and achievement. These groups also differed as a function of grade level, gifted status, and implicit theory of ability.