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For two-group comparisons in which the assumption of normality is not tenable, previous researchers have specifically emphasized that the Wilcoxon rank-sum test provides greater power compared to the independent samples t-tests. Most empirical studies have examined robustness and power when the two populations show the same pattern of non-normality. Given this, the current simulation study examines Type I error control and statistical power of the independent samples t-tests, the Wilcoxon rank-sum test, and nonparametric bootstrap under group-specific non-normal distributional conditions, various sample sizes, and effect sizes found in educational research. Recommendations will be provided and implications for practice are discussed.