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To address race/gender gaps in STEM, this study examines a factor important to retention in the field – student science identity. This study takes an intersectional perspective to determine the effects of race and gender on science identity and how these effects are mediated by science self-efficacy. Using path analysis, the results demonstrate that science self-efficacy fully mediates the effects of race/gender on science identity for White and Asian females and partially mediates these effects for Black males and Hispanic females. However, science self-efficacy does not mediate these effects for Black females and Hispanic males. Ultimately, these results point toward the need for a continued interrogation of the factors that contribute to disidentification with science for students of color.