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The relevance of pedagogical intervention for scientific reasoning in science education and outside the classroom is prevalent. The current state of research includes intervention studies; however, misses to inform researchers and practitioners about the bigger picture: What is the magnitude of the effect of interventions for scientific reasoning and which factors in the intervention explain differences between studies? This meta-analysis brings together and analyzes effect sizes taken from 15 studies. The results show that scientific reasoning can successfully be fostered with a large mean effect, though the success of interventions depend on moderator variables such as the learning activities pursued in the intervention.