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This paper investigates the impact of using different item pool designs on the performance of item selection algorithms in cognitive diagnosis computerized adaptive testing (CD-CAT). Three different item pool designs were considered in a simulation study. First, Design 1 consisted of items with all possible 2^K-1 q-vectors where K is the number of attributes. Second, Design 2 consisted of items with only a small number of attributes (e.g., one- or two-attribute items). Last, Design 3 consisted of items with only a large number of attributes (e.g., four- or five-attribute items). The results of this study showed that Design 1 and Design 2 resulted in similar mean test lengths; however, Design 3 yielded longer mean test lengths compared to the others.