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Digitally simulated science laboratories (DSSLs) are popular in science classrooms as learning and assessment tools. DSSLs have been shown to improve student achievement when administered properly so that students actively engage with science concepts in the digital environment. This research study investigated two treatments – a learning error intervention (LEI) and pre-laboratory activity – that were expected to enhance students’ performance on a DSSL. The results indicated students who received the LEI scored higher on higher-order portions of a DSSL and on a post-DSSL knowledge assessment. Additionally, students who were administered the pre-laboratory activity reported lower levels of test anxiety. These findings provide evidence that treatments such as an LEI and pre-laboratory activity can benefit students’ DSSL performance and socio-emotional experience.