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This work identifies and unpacks three key decision points in a systematic mixed research synthesis (SMSR), a mixed methods approach to research synthesis. The research community has increasingly recognized the value of synthesis studies in expanding our understanding of phenomena. Mixed-methodology broadly has also gained ground as a pragmatic approach to research investigations. By leveraging mixed methods approaches in a synthesis review, SMSR enables a broad and integrated summary of existing research on a topic. Yet SMSRs can be challenging to undertake given the complexity of working with research synthesis and mixed methods requirements. This work therefore assists novice researchers in navigating critical decisions in SMSRs, and provides examples in the form of two case studies.