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With the advancement in brain research, neuroscience researchers have been collectively informed our understanding of reading-related processes. Despite an extensive body of literature, educators are not aware of specific neuroimaging findings related to phonological processing and word reading. Therefore, this integrative review seeks to disseminate this information to an audience of educators. Findings discussed in this review include early reading development, the reading network, and developing models of the reading processes from a neuroscientific perspective. This integrative review will contribute to educators’ understanding of brain connectivity in relation to phonological processing and word reading ability. An enhanced understanding of neural connectivity and reading will lay the foundation for a deeper dialogue among reading theory, policy, classroom instruction, and brain research.