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In the era of proliferating data as well as analysis techniques, traditional analysis methods are often coupled with machine learning. In particular, regSEM (regularized structural equation modeling), a combination of SEM (a traditional method) and regularization (machine learning), has been proposed as a variable selection method in the framework of SEM. Specifically, this simulation study focused on regularized multiple-indicators multiple-causes (regMIMIC) in the presence of missing data. A total of 48 Monte Carlo simulation conditions included missingness mechanisms (MAR, MNAR), missing rates (5%, 30%), missing data techniques (listwise deletion, k-NN), sample sizes (500, 2000), and analysis methods (MLE, LASSO, MCP). Scientific importance of the study was discussed as well as further research topics.