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In this paper, I discuss how knowledge production in HIV/AIDS education research creates “makes up” and how their lives are governed in the name of health intervention. I also examine how difference is produced through HIV/AIDS education, that is, how concepts, pedagogies, and curriculum content produced through scientific research influence how the “kinds of people” are conceptualized. Although my geographical focus is Africa, I engage ideas of internationalization of HIV/AIDs education as a way of circulating knowledge about the pandemic. I use the notion of “making up” people as conceptualized by Ian Hacking, who argues that through dynamic nominalism, different kinds of people and human acts come into being at the same time we are inventing them (1986).