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This study explored the mediation relationship among stress, insecure attachment (attachment avoidance/attachment anxiety), and avoidance coping. In addition, the study explored social support-seeking and trait resilience as moderators that intervened the mediation relationship. Participants were 250 college students in the U.S. Hayes’s (2018) PROCESS macro for SPSS was applied to test the mediation and moderated mediation models in the study. Results showed that although social support-seeking could not reduce the possibility of stress activating insecure attachment, a high level of social support-seeking could effectively intervene the influence of insecure attachment on avoidance. An examination of the social support-seeking measure revealed information for practical implications.