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Empirical studies have shown that animations are beneficial for learning and few studies have examined the synergistic effects of self-explanation with animated maps or paragraphs in learning chemistry concepts. The present study investigates the effects of animated concept map + self-explanation, animated paragraph + self-explanation, animated concept map only, and animated paragraph only on learning gas concepts in a large introductory chemistry class. Participants (n = 650) were randomly assigned to one of four groups to learn chemistry concepts. The result indicates that self-explanation did not improve chemistry learning performance. A univariate ANOVA F-test indicated no main effect of treatment on post-test and open-ended scores, but there was a main effect of treatment on recall scores.