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Building upon previous research, we examined the association between marijuana use and academic performance among adolescents through secondary data analyses of the Minnesota Student Survey data (n = 170,114 in 2019; n =135,447 in 2022). Employing propensity score matching to control for potential confounding factors, results from students in grades 8, 9, and 11 indicated a consistent negative association between marijuana use and academic performance. Students who reported regular marijuana use (six or more times in the past thirty days) exhibited significant average GPA deficits of approximately 0.4 and 0.5 points, respectively, compared to non-marijuana users, even after accounting for background variables.