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Preparing for the United States Medical Licensing Examination (USMLE) sequence is often a stressful time for medical students that may lead to mental and physical health difficulties. An open-ended web-based questionnaire was developed to explore factors that contribute to student well-being during their USMLE Step 1 preparation. 477 medical students responded to the survey (response rate of 29.8%). Responses were analyzed using two text mining methods: topic modeling and sentiment analysis. Overall, some students engaged in a variety of well-being promoting activities, while others felt they had to forgo certain activities due to perceived time pressure in favor of studying for Step 1. These results may help inform school-level interventions aimed at supporting students as they prepare for licensure examinations.