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What explains the widely varied policy responses to Covid-19 inside federal countries? This study shows that subnational variation in policy coordination and stringency in federations is mainly driven not by epidemiological, demographic and socioeconomic forces but by political factors, especially partisanship and intergovernmental power struggles. With a combination of statistical analysis and qualitative case studies of state-level policies in Brazil, Mexico and the United States, the study finds that subnational policy responses to the pandemic are largely a function of partisanship and the politically determined balance of power between presidents and state governors.