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Educational mobility is celebrated as a pathway to health equity, yet this study reveals a troubling exception. Using five waves of South Africa's National Income Dynamics Study (2008–2017; N = 26,838 person-waves), we examine how intergenerational educational trajectories shape neighborhood effects on hypertension. We uncover mobility-contingent immunity: while non-mobile individuals gain significant protection against hypertension in high-opportunity neighborhoods (OR: 0.85, 95% CI [0.73, 0.99]), upwardly mobile individuals remain physiologically immune to these benefits. Despite educational achievement and residence in protective environments, upwardly mobile South Africans maintain elevated hypertension prevalence (~45%), regardless of neighborhood quality. We theorize that this reflects a blocked opportunity structure, in which the psychosocial costs of navigating status inconsistency in post-apartheid society neutralize residential advantages. When mobility itself exacts a physiological toll, health equity demands structural transformation beyond individual achievement.