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Does majoring in certain fields make people less prosocial? Many have speculated that disciplines such as business and economics, which conceive humans as primarily self-interested, inhibit cooperation and prosocial behavior in those who pursue them. However, self-selection has been difficult to rule out. To address this question, I focus on attempted blood donation as a measure of prosocial behavior, use Swedish population registers that cover all first-time university applicants between 1993 and 2018, and employ a fuzzy regression discontinuity design that leverages Sweden’s centralized college admission system. Descriptive analyses reveal substantial variation in blood donor prevalence across one-digit ISCED-2013 fields, ranging from 11% in ICTs to 28% in health and welfare. While I find evidence of self-selection, quasi-experimental estimates provide strong evidence that college major enrollment causally affects the probability of becoming a blood donor, at times, but not always, consistent with expectations about business-oriented fields. Additional analyses uncover peer effects as an important underlying mechanism, while also suggesting that curricular content and other major-specific factors play a role. Documented effects persist for up to eight years after college entry.