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Diabetes mellitus is a chronic disease of public health concern globally; it is estimated to be the seventh leading cause of death by 2030. About 7 million people are diagnosed of the disease yearly, with an estimated 1.5 million deaths in 2019. While Texas is ranked among the top 10 states with the highest diabetes disease prevalence rates in the U.S. This study examined association between ethnicity and other variables and how they produce diabetes disease, guided by the Disease Ecology Framework. It provides recommendations on utilizing informed decision-making as a strategy in prevent diabetes, considering the evolving healthcare landscape.