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Powerful institutions are often regarded as the primary news definers. However, in contemporary China, this is not always true. Using the Hepatitis B epidemic as a case study, I find that the news construction on this issue does not totally grant privilege to the political establishment. Rather, in the news battle of making HBV into a social problem, especially surrounding the topic of discrimination, grassroots NGO activists, as important policy entrepreneurs, not only affect the construction of media agenda but also successfully change the state’s policy.