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Mental health problems among young adults have become a significant public health concern. Stressful life events are viewed as the leading cause of psychological distress. Self-disclosure, however, has been found to buffer the deleterious impact of stress on mental health. Recent studies show that college students are likely to talk about their problems on social network sites (SNSs), but it is unclear to what extent they benefit from doing that. This study examined the effect of self- disclosure on SNSs on young adults’ mental health. Survey data were collected from a probability sample of 560 university students. The results show that self-disclosure on Facebook moderates the relationship between stressful life events and mental health. Facebook disclosure was also positively associated with enacted social support on Facebook, which led to increased perceived social support, enhanced life satisfaction, and reduced depression. SNSs, therefore, serve as a promising avenue for delivering health care and intervention.