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Message framing was explored through the analysis of respondentsÂ’ (N = 312) message reactions, perceived manipulative intent, and psychological reactance to PSAs inducing viewers to become organ donors. Results indicated respondents watching the gain-framed PSA had more favorable reactions and experienced less psychological reactance and perceived manipulative intent than those watching the loss-framed PSA. Perceived manipulative intent was found to mediate the relationship between framing and message reactions and psychological reactance partially mediated the relationship.