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I study marine plastic pollution in Newfoundland, Canada, where the contamination of human food webs by plastics and their associated industrial chemicals is a primary concern for impacts to human health, commercial livelihoods, and local cultures. Drawing on Kim Tallbear’s work on Indigenous bioscience, Eve Tuck’s work on refusal in research, and feminist science and technology scholars like Michelle Murphy, this presentation outlines some of our lab’s efforts to incorporate feminist imaginaries and world-making practices into scientific methodologies on marine plastic pollution, and is an invitation to think with others through the everyday protocols of the laboratory.