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1-073 - Early Risk Factors for the Development of Internalizing and Externalizing Symptomatology
Thu, April 6, 12:00 to 1:30pm, Austin Convention Center, Meeting Room 12ASession Type: Paper Symposium
Integrative Statement
Internalizing and externalizing symptoms are common problems during childhood and adolescence. To prevent the occurrence of these symptoms, it is important to study early predisposing risk-factors. In this symposium, we approach this problem from a multidisciplinary and translational perspective. In four presentations we discuss novel insights on the relevance of reactivity in neuroendocrine and behavioral stress-systems indicating that both hypo- and hyper-reactivity in these stress-systems during childhood and adolescence may constitute important risk-factors for developing internalizing and externalizing symptoms. First, novel results from a primate model of behavioral inhibition are presented suggesting a neural network of behavioral inhibition-related brain regions that may underlie the development of internalizing symptoms. Second, by bridging to human research, recent findings in adolescents are presented, indicating that prolonged behavioral inhibition, as operationalized by poor recovery of freezing from acute stress forms a risk-factor for internalizing problems. In the last two presentations, behavioral and endocrine markers are linked to early-life-stress. New data from a traumatized adolescent sample and from the Minnesota-International-Adoption-Project are presented showing that exposure to early-life-stress contribute to both internalizing and externalizing symptoms. In all presentations, the role of Hypothalamic-Pituitary-Adrenal-axis (HPA) in the observed symptomatology and risk-markers are discussed. Finally, a comprehensive model is presented detailing when and for whom early-life-stress may result in hypo- versus hyper-reactivity of HPA-axis and how these distinct mechanisms may increase risk on internalizing and externalizing symptoms, respectively. To conclude, we present emerging evidence for the role of distinct neuroendocrine and behavioral risk-factors for developing internalizing and externalizing symptoms.
Sub Unit
Chairs
Karin Roelofs, Behavioural Science Institute; Donders Institute for Brain, Cognition and Behaviour, Radboud University, The Netherlands
Hannah C. M. Niermann, Behavioural Science Institute; Donders Institute for Brain, Cognition and Behaviour, Radboud University, The Netherlands
Individual Presentations
The Neural Substrates of Anxious Temperament in Young Rhesus Monkeys - Presenting Author: Andrew S. Fox, Department of Psychology, University of California, Davis and California National Primate Research Center; Jonathan A. Oler, Department of Psychiatry, University of Wisconsin-Madison; Alexander J. Shackman, Department of Psychology, University of Maryland; Rasmus M. Birn, Department of Psychiatry, University of Wisconsin-Madison; Andrew A. Alexander, Department of Medical Physics, University of Wisconsin-Madison; Richard J. Davidson, Department of Psychology, University of Wisconsin-Madison; Ned H. Kalin, Department of Psychiatry, University of Wisconsin-Madison
Stress-Induced Freezing Responses in Humans: Relation with Basal Cortisol and Internalizing Symptoms - Presenting Author: Hannah C. M. Niermann, Behavioural Science Institute; Donders Institute for Brain, Cognition and Behaviour, Radboud University, The Netherlands; Bernd Figner, Behavioural Science Institute; Donders Institute for Brain, Cognition and Behaviour, Radboud University, The Netherlands; Anna Tyborowska, Behavioural Science Institute; Donders Institute for Brain, Cognition and Behaviour, Radboud University, The Netherlands; Jacobien van Peer, Behavioural Science Institute; Donders Institute for Brain, Cognition and Behaviour, Radboud University, The Netherlands; Antonius H. N. Cillessen, Developmental Psychology, Behavioural Science Institute, Radboud University; Karin Roelofs, Behavioural Science Institute; Donders Institute for Brain, Cognition and Behaviour, Radboud University, The Netherlands
Dimensions of Adversity, Physiological Reactivity, and Externalizing Psychopathology in Adolescence: Deprivation and Threat - Presenting Author: Daniel S. Busso, Harvard Graduate School of Education; Katie McLaughlin, University of Washington; Margaret A. Sheridan, University of North Carolina, Chapel Hill
Early Life Stress and Externalizing Problems in Post-Institutionalized Children and Youth - Presenting Author: Megan Gunnar, Institute of Child Development, University of Minnesota, Minneapolis, Minnesota; Kalsea J Koss, Princeton University; Camelia E. Hostinar, University of California -Davis; Elisa A. Esposito, Psychology, Widener University, Chester, Pennsylvaniva; Tahl Frenkel, Interdisciplinary Center, Herzliya, Herzliyya, Israel