1-169 - Developmental Psychopathology and the Brain: Impact of Challenging Early Social Contexts on Brain Structure and Function

Session Type: Paper Symposium

Integrative Statement

A compelling emerging literature in developmental neuroscience indicates that compromised social contexts during childhood have notable and lasting influence on brain development. Furthermore, altered brain development can have consequences for affective functioning and psychopathology. This paper symposium addresses the neurodevelopmental impact of micro- to macro-level social-context risks: maternal inflammation, adverse family experiences, and poverty. The featured papers cover a range of functional and structural neural indices, with particular emphasis on the connectivity of brain networks. All three papers take a developmental psychopathology approach, focusing on early life and drawing on prospective, longitudinal studies of high-risk populations. Paper one examines prenatal maternal inflammation and neonates’ within- and between-network connectivity. Paper two investigates associations between family relationship risk from ages 5-10 and neural response to reward at ages 16-19. Paper three addresses the relation of chronicity of public assistance in childhood to white matter tract integrity in adolescence. Each paper delves deeply into a specific realm of social-context risk and a specific aspect of brain development, providing both complementarity and consistency among the papers. The symposium’s chair and discussant have expertise in the impact of social context on neurodevelopment and will integrate the findings presented with an eye to developmental psychopathology. Furthermore, the focus aligns closely with two of this meeting’s themes: Poverty, Inequality and Developmental Science; and Neuroscience and Child Development. In all, this symposium will advance knowledge about the social context of brain development, promote audience discussion about levels and types of social-context influence, and generate hypotheses about mechanisms of psychopathology.

Sub Unit

• Biology and Neuroscience

Chair

• Erika E Forbes, University of Pittsburgh

Discussant

• Amanda E Guyer, University of California, Davis

Individual Presentations

• Newborn Functional Connectivity is Associated with Maternal Inflammation during Pregnancy - Presenting Author: Marc D Rudolph, Oregon Health and Science University; Alice M Graham, Oregon Health and Science University; Claudia Buss, UCI Development, Health and Disease Research Program, University of California Irvine, USA; Jerod Rasmussen, University of California, Irvine; Sonja Entringer, UCI Development, Health and Disease Research Program, University of California Irvine, USA; Pathik Wadhwa, UCI Development, Health and Disease Research Program, University of California Irvine, USA; Damien Fair, Oregon Health and Science University

• Early Family Relationship Risk, Development of Neural Reward Systems, and Adolescent Depression - Presenting Author: Erika E Forbes, University of Pittsburgh; Neil P Jones, University of Pittsburgh; Melynda D Casement, University of Pittsburgh; Amanda E Guyer, University of California, Davis; Arpita Mohanty, University of Pittsburgh; Alison Hipwell, University of Pittsburgh; Kathryn Keenan, University of Chicago

• Childhood Economic Disparity and Alterations in White Matter Integrity in Late Adolescence - Presenting Author: Rajpreet Chahal, University of California Davis; Shawn A Rhoads, University of California, Davis; Alison Hipwell, University of Pittsburgh; Erika E Forbes, University of Pittsburgh; Kathryn Keenan, University of Chicago; Amanda E Guyer, University of California, Davis